How Many Cycles of Letrozole Shall I Take Before Getting Pregnant?

I was surprised when my doctor gave me Letrozole to help me out with my irregular ovulation. If you are familiar with Femara, it is the brand name of Letrozole. I learned that the drug is a treatment for breast cancer. Yet, when it proves effective to treat women with Polycystic Ovary Syndrome (PCOS), it’s been used ever since to treat unexplained infertility.

This oral medication induces ovulation, giving a chance to women like me to conceive. I wonder how many cycles of Letrozole shall I take to get pregnant?


How does Letrozole work?

Letrozole functions as prevention of androgens to convert into estrogens in your body. You see, when stopping estrogen, the pituitary glands receive a signal to release follicle stimulating hormone (FSH) that’s responsible in stimulating the ovary to produce an ovum. If you are on this medication, you may have the chance to release multiple eggs because you tend to have more FSH compared to a woman who is ovulating naturally. In this case, you have a higher possibility of conceiving twins.

As instructed, I started the treatment during my 4th day of the cycle, one pill daily for 5 days. I should ovulate 4-7 days after the last pill. Most importantly, 1-3 days before I ovulate is the best timing to be intimate with your husband. If you find it hard to determine if you’re ovulating, get an ovulation predictor kit.

How many cycles of Letrozole shall I take before getting pregnant?

Not everyone has the same experience with Letrozole. Some got pregnant on their 2nd cycle, others on their ninth try. However, some say a study shows that 27.5% of women with PCOS who took this treatment got pregnant within 5 cycles and successfully gave birth to healthy babies. Whatever it may be, I am determined to push through with the medication.

I chat with my friends who are also taking Letrozole (a group with PCOS issues), and their response is more like an existing data there is. One got pregnant after 5 cycles, another was successful after 9 cycles, and my neighbor announced it after 2 cycles. I am on my third cycle now and still counting.

How do you know that Letrozole treatment is for you?

It makes sense to consult a doctor for this treatment. This drug is for women who have ovulating issues. Take note that doctors recommend Letrozole only if you have no known medical conditions preventing ovulation.

Letrozole has two functions; it is superovulation and ovulation induction. Hence, if you qualify to receive treatment, your reason may be one of the two.

What are the side effects of Letrozole?

One thing is for sure; Letrozole does not cause mood changes or causes abnormality in the endometrial lining or cervical mucus. Yet, you need to remember that you are not allowed the take the medication when you are breastfeeding. Doing so will affect the hormones of your baby

Letrozole has a few side effects per the record. Complaints about these are minimal and deem temporary.  All of the symptoms occur during the treatment but eventually go away once they stopped taking the pills. However, if you feel pain while in medication, you need to tell your doctor immediately.

These side effects are not serious. Nevertheless, if you find these indications as severe and won’t go away, you must inform your doctor.

  • Leg cramps
  • A headache
  • Fatigue
  • Dizziness
  • Hot flashes
  • Breast discomfort
  • Nausea
  • Vomiting
  • Visual disturbances
  • Night Sweats
  • Loss of appetite
  • Constipation
  • Diarrhea
  • Heartburn
  • Stomach pain
  • Changes in weight
  • Muscle, joints, and bone pains
  • Weakness
  • Swelling of the hands, feet, ankles, and lower part of the legs
  • Insomnia
  • Hair loss
  • Chest pain
  • Hives
  • Itching
  • Difficulty of breathing

Precautions you need to keep in mind:

  • Inform your doctor if you are allergic to some medications before Letrozole treatment.
  • Give your doctor a list of your current vitamins, supplements, prescription, non-prescription, and herbal products before taking Letrozole.
  • Highlight certain conditions like high cholesterol, osteoporosis, or liver illness.
  • Letrozole can make you feel drowsy. Refrain from driving when you are under medication.


I know that not all patients taking this treatment are successful. No matter how many cycles of Letrozole I take to get pregnant, I am willing to try. With all the positive feedback from testimonies and support from friends and family, I’m sure it’ll be effective.

If you are also planning to take the same medication, take note of the side effects so that you will know what to expect. Stick to your doctor’s rules and hope for the best.

Sarah Palmer

Hi! I'm Sarah. My husband and I have a beautiful little girl; plus we’re anxiously awaiting the arrival of Baby #2, so this is a very exciting time for us. Throughout this amazing journey called Parenthood, I’ve learned so much and love sharing my experiences with other parents at I'd love to share my discoveries with you too!

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